Ca2+-ATPases in the cochlear duct

Academic Article

Abstract

  • Differing levels of the Ca -ATPase enzymes that reside on the plasma membrane (PM) and on the endoplasmic reticulum (ER) were identified in individual rat cochlear tissues by the use of a semi-quantitative enzyme-linked immunosorbent assay (ELISA). Unlike other studies, a specific antibody to PM Ca -ATPase was used to detect significantly greater levels (about 2x) of PM Ca -ATPase in the stria vascularis (SV) than that in the spiral ligament (SL) and organ of Corti (OC) tissues. Similarly, levels of ER Ca -ATPase were also significantly higher in the SV than in the SL and OC tissues. The presence of ER Ca -ATPase in the tissues of the SV has not been demonstrated previously. Given the importance of Ca homeostasis in the inner ear, the statistically significantly higher densities of both PM and ER Ca -ATPase measured in the SV relative to the SL and OC regions would indicate tissue-specific responses to fluctuations in systemic and local Ca concentrations. 2+ 2+ 2+ 2+ 2+ 2+ 2+ 2+
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Curtis LM; Garg LC; Rarey KE
  • Start Page

  • 553
  • End Page

  • 558
  • Volume

  • 117
  • Issue

  • 4