© 2017 The Society for Adolescent Health and Medicine Purpose: Although motor vehicle crashes are the leading cause of death for adolescents, there is a scarcity of research addressing adolescents’ lack of pre-licensure practical driving experience, which is theorized to increase their post-licensure crash risk. Methods: Utilizing police-reported crashes and survey data from a randomized and quasi-randomized trial (n = 458 adolescents, 16 or 17 years of age at enrollment), the impact of a parent-directed supervised practice driving intervention and a comprehensive on-road driving assessment (ODA) with feedback was evaluated on adolescent drivers’ motor vehicle crashes involvement. Results: Compared with the control condition, a nonsignificant 20% relative reduction in risk was observed for the parent-directed intervention: adjusted hazard ratio =.80 (95% confidence interval [CI].44, 1.43); the unadjusted absolute risk reduction was 1.1% (95% CI −4.4, 7.1). Exposure to the ODA resulted in an 53% relative reduction of risk: adjusted hazard ratio =.47 (95% CI.24,.91); the unadjusted absolute risk reduction was 5.4% (95% CI −.3, 10.7). Conclusions: Comprehensive ODA might be protective for adolescents; however, additional research is needed.