An animal model of bulimia nervosa: Opioid sensitivity to fasting episodes

Academic Article


  • A group of female rats was deprived and maintained at 75-80% of body weight at three different times during development. Following recovery to normal weight, food intake was measured with and without butorphanol tartrate, a kappa-sigma agonist, 8 mg/kg SC. Animals with a history of deprivation (DEP) showed an increase in postrecovery feeding when they were tested at normal body weight and not food deprived. More importantly, butorphanol prolonged food intake in the 3-h eating test only in the rats with a developmental history of food restriction. A developmental history of fasting in eating disorders may trigger changes in opiate systems that result in atypical feeding behavior in the adult. © 1991.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Hagan MM; Moss DE
  • Start Page

  • 421
  • End Page

  • 422
  • Volume

  • 39
  • Issue

  • 2