Suppression of peptide YY-induced hyperphagia by terbutaline

Academic Article


  • Central administrations of neuropeptide Y and peptide YY (PYY) produce robust increases in food intake, and this response may be contingent upon the availability of insulin. In contrast, β2-adrenergic agonists decrease food intake, and this effect also appears to be dependent on circulating insulin. To investigate a possible interaction between PYY and β2-adrenergic function, rats were given systemic injections of terbutaline, a β2 agonist, at doses of 0, 5, 10, and 50 mg/kg prior to injections of 0.57 nmol PYY in the paraventricular nucleus of the hypothalamus. Terbutaline pretreatment significantly decreased feeding elicited by PYY in a dose-dependent fashion. This suggests that β2-adrenoreceptor activity is involved in PYY-induced feeding. © 1993.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Hagan MM; Moss DE
  • Start Page

  • 679
  • End Page

  • 681
  • Volume

  • 46
  • Issue

  • 3