Synthesis and Properties of 2-Styrylthiopyrimidin-6(1H)-ones

Academic Article


  • Addition of 2-thioxo-1,2,3,4-tetrahydropyrimidin-4-ones to phenylacetylene in superbasic medium (DMSO-KOH) proceeds regio- and stereoselectively with formation of 2-styrylthiopyrimidin-6(1H)-ones. Alkylation of these products with allyl bromide in alkaline medium occurs at the N1 and oxygen atoms. 1-Allyl-2-styrylthiopyrimidine-6(1H)-one undergoes intramolecular cyclization into oxazolo[3,2-c]pyrimidine system on treatment with iodine.
  • Author List

  • Kim DG; Shmygarev VI; Kharlampieva EP; Vorob'ev DV
  • Start Page

  • 1341
  • End Page

  • 1342
  • Volume

  • 33
  • Issue

  • 9