The podocyte cytoskeleton: Key to a functioning glomerulus in health and disease



  • Background: Proteinuria is a cardinal sign of chronic kidney disease, which is a major healthcare problem that affects millions of people worldwide. Recent advances in molecular genetics and cell biology have revealed the podocyte as the primary functional regulator of the tri-layered glomerular filter. Since podocyte foot processes (FP) and their interposed slit diaphragms (SD) form the final barrier to protein loss, podocyte injury causes proteinuric kidney disease.
  • Digital Object Identifier (doi)

    Pubmed Id

  • 11483154
  • Start Page

  • 22
  • End Page

  • 53
  • Volume

  • 183