RNA sequencing and proteomics approaches reveal novel deficits in the cortex of Mecp2-deficient mice, a model for Rett syndrome

Academic Article

Abstract

  • BACKGROUND: Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by mutations in the transcriptional regulator MeCP2. Much of our understanding of MeCP2 function is derived from transcriptomic studies with the general assumption that alterations in the transcriptome correlate with proteomic changes. Advances in mass spectrometry-based proteomics have facilitated recent interest in the examination of global protein expression to better understand the biology between transcriptional and translational regulation.
  • Authors

    Published In

  • Molecular Autism  Journal
  • Digital Object Identifier (doi)

    Author List

  • Pacheco NL; Heaven MR; Holt LM; Crossman DK; Boggio KJ; Shaffer SA; Flint DL; Olsen ML
  • Start Page

  • 56
  • Volume

  • 8