Molecular profiling of mammary analog secretory carcinoma revealed a subset of tumors harboring a novel ETV6-RET translocation: Report of 10 cases

Academic Article

Abstract

  • ETV6 gene abnormalities are well described in tumor pathology. Many fusion partners of ETV6 have been reported in a variety of epithelial, mesenchymal, and hematological malignancies. In salivary gland tumor pathology, however, the ETV6-NTRK3 translocation is specific for (mammary analog) secretory carcinoma, and has not been documented in any other salivary tumor type. The present study comprised a clinical, histologic, and molecular analysis of 10 cases of secretory carcinoma, with typical morphology and immunoprofile harboring a novel ETV6-RET translocation.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Skalova A; Vanecek T; Martinek P; Weinreb I; Stevens TM; Simpson RHW; Hyrcza M; Rupp NJ; Baneckova M; Michal M
  • Start Page

  • 234
  • End Page

  • 246
  • Volume

  • 42
  • Issue

  • 2