The etiology of most human diseases involves complicated interactions of multiple environmental factors with the individual genetic/epigenetic background initially generated during early development. Epigenetic mechanisms are believed to play a key role in regulating early reprogramming processes that occur during embryogenesis. Recently, transgenerational epigenetics have received extensive attention due to its ability to prewrite individual epigenetic profiles that lead to consequences on the adult phenotype formation and disease onset. Environmental-based factors, such as nutrition with properties influencing epigenetic processes, are believed to have preventive effects on many human diseases such as cancer. Exposure to these epigenetic dietary compounds during a crucial time of development may result in changes in specific epigenetic patterns that influence phenotypic variation, subsequently leading to different susceptibilities to diseases later in life and throughout generations. In this chapter, I assess the current advances in transgenerational epigenetic gene regulation and human disease control. Enhanced understanding of the important role of early life epigenetics control and how environmental factors affect this process will lead to beneficial health outcomes in the next generation.