© 2005 by Taylor & Francis Group, LLC. For the clinician faced with a child manifesting tremor, every attempt should be made to consider a reasonable differential diagnosis. However, most cases of childhood tremor do not require specific therapy, but rather treatment of an underlying cause if it exists. In children with tremor of a severity to result in some degree of disability or impairment, therapeutic options exist, although they have yet to be studied carefully in children. The clinician is urged to carefully weigh the potential risks when considering a drug intervention, and to develop reasonable expectations with respect to possible outcomes.