The hormone resistin links obesity to diabetes

Academic Article

Abstract

  • Diabetes mellitus is a chronic disease that leads to complications including heart disease, stroke, kidney failure, blindness and nerve damage. Type 2 diabetes, characterized by target-tissue resistance to insulin, is epidemic in industrialized societies and is strongly associated with obesity; however, the mechanism by which increased adiposity causes insulin resistance is unclear. Here we show that adipocytes secrete a unique signalling molecule, which we have named resistin (for resistance to insulin). Circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity. Administration of anti-resistin antibody improves blood sugar and insulin action in mice with diet-induced obesity. Moreover, treatment of normal mice with recombinant resistin impairs glucose tolerance and insulin action. Insulin-stimulated glucose uptake by adipocytes is enhanced by neutralization of resistin and is reduced by resistin treatment. Resistin is thus a hormone that potentially links obesity to diabetes.
  • Published In

  • Nature  Journal
  • Digital Object Identifier (doi)

    Author List

  • Steppan CM; Bailey ST; Bhat S; Brown EJ; Banerjee RR; Wright CM; Patel HR; Ahima RS; Lazar MA
  • Start Page

  • 307
  • End Page

  • 312
  • Volume

  • 409
  • Issue

  • 6818