Date fruit continue to be a major dietary staple of people living in many parts of the world today. Therefore, dates have great importance in providing nutrition and maintaining health to mankind and warrant detailed study on their health benefits. The potential antioxidant and antimutagenic activities and health benefits of dates have been published only recently. Even though dates are a sugar-packed fruit (dried or fresh), consumption of certain varieties of dates do not induce any metabolic and inflammatory markers that are associated with metabolic syndrome and related diseases. Only recently have clinicians and health professionals realized the potential health benefits of dates, but few clinical studies have been published demonstrating their health benefits. More scientific investigations are necessary to validate their beneficial effects and mechanisms of action, as well as to appreciate their role as a functional food for populations around the world.