Neural Mechanisms Contributing to Dysphagia in Mouse Models.

Academic Article

Abstract

  • Investigative research into curative treatments for dysphagia is hindered by our incomplete understanding of the neural mechanisms of swallowing in health and disease. Development of translational research models is essential to bridge this knowledge gap by fostering innovative methodology. Toward this goal, our laboratory has developed a translational research assessment tool to investigate the neural mechanistic control of swallowing in unrestrained, self-feeding mice. Here we describe our initial development of synchronous brainstem neural recordings with a videofluoroscopic swallow study assay in healthy mice across the life span. Refinement of this combined methodology is currently underway. Ultimately, we envision that this assessment tool will permit systematic analysis of therapeutic interventions for dysphagia in preclinical trials with numerous mouse models of human conditions that cause dysphagia, such as amyotrophic lateral sclerosis, Parkinson's disease, stroke, and advanced aging.
  • Keywords

  • dysphagia, electrophysiology, mice, swallowing, translational research, videofluoroscopy, Animals, Central Nervous System Diseases, Deglutition Disorders, Disease Models, Animal, Electrophysiology, Fluoroscopy, Mice, Mice, Inbred C57BL, Translational Medical Research, Video Recording
  • Digital Object Identifier (doi)

    Author List

  • Hinkel CJ; Sharma R; Thakkar MM; Takahashi K; Hopewell BL; Lever TE
  • Start Page

  • 303
  • End Page

  • 306
  • Volume

  • 155
  • Issue

  • 2