Development of prodrugs for enzyme-mediated, tumor-selective therapy

Academic Article

Abstract

  • Anticancer enzyme/prodrug approaches to therapy are designed to activate prodrugs specifically at tumor loci, to achieve antitumor responses with minimal toxicity. The equivocal success of these approaches thus far has led to searches for more efficient combinations. This mini-review evaluates and compares characteristics of seven selected enzyme/prodrug combinations, and discusses goals for future development of effective combinations. © 2005 Bentham Science Publishers Ltd.
  • Digital Object Identifier (doi)

    Author List

  • Yoon KJ; Potter PM; Danks MK
  • Start Page

  • 107
  • End Page

  • 113
  • Volume

  • 5
  • Issue

  • 2