Antimicrobial drug prescription and Neisseria gonorrhoeae susceptibility, United States, 2005–2013

Academic Article


  • We investigated whether outpatient antimicrobial drug prescribing is associated with Neisseria gonorrhoeae antimicrobial drug susceptibility in the United States. Using susceptibility data from the Gonococcal Isolate Surveillance Project during 2005–2013 and QuintilesIMS data on outpatient cephalosporin, macrolide, and fluoroquinolone prescribing, we constructed multivariable linear mixed models for each antimicrobial agent with 1-year lagged annual prescribing per 1,000 persons as the exposure and geometric mean MIC as the outcome of interest. Multivariable models did not demonstrate associations between antimicrobial drug prescribing and N. gonorrhoeae susceptibility for any of the studied antimicrobial drugs during 2005–2013. Elucidation of epidemiologic factors contributing to resistance, including further investigation of the potential role of antimicrobial drug use, is needed.
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    Digital Object Identifier (doi)

    Author List

  • Kirkcaldy RD; Bartoces MG; Soge OO; Riedel S; Kubin G; Del Rio C; Papp JR; Hook EW; Hicks LA
  • Start Page

  • 1657
  • End Page

  • 1663
  • Volume

  • 23
  • Issue

  • 10