Host-induced epidemic spread of the cholera bacterium

Academic Article


  • The factors that enhance the transmission of pathogens during epidemic spread are ill defined. Water-borne spread of the diarrhoeal disease cholera occurs rapidly in nature, whereas infection of human volunteers with bacteria grown in vitro is difficult in the absence of stomach acid buffering. It is unclear, however, whether stomach acidity is a principal factor contributing to epidemic spread. Here we report that characterization of Vibrio cholerae from human stools supports a model whereby human colonization creates a hyperinfectious bacterial state that is maintained after dissemination and that may contribute to epidemic spread of cholera. Transcriptional profiling of V. cholerae from stool samples revealed a unique physiological and behavioural state characterized by high expression levels of genes required for nutrient acquisition and motility, and low expression levels of genes required for bacterial chemotaxis.
  • Published In

  • Nature  Journal
  • Digital Object Identifier (doi)

    Author List

  • Merrell DS; Butler SM; Qadri F; Dolganov NA; Alam A; Cohen MB; Calderwood SB; Schoolnik GK; Camilli A
  • Start Page

  • 642
  • End Page

  • 645
  • Volume

  • 417
  • Issue

  • 6889