Localization of four antigenic sites involved in Venezuelan equine encephalomyelitis virus protection

Academic Article

Abstract

  • Stable neutralization and protection escape variants of a virulent strain (Trinidad Donkey) of the VEE virus were selected by monoclonal antibodies (MAbs). Determination of nucleotide sequences of nine variants revealed a clustering of single mutations in four regions of the E1 and E2 glycoproteins. Involvement of amino acid residues 206 (site E1-1), 57 and 59 (site E2-2), 180, 182, 213, 214 and 216 (site E2-6) and 232 (site E2-3) in protective epitopes was demonstrated. © 1994 Springer-Verlag.
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    Digital Object Identifier (doi)

    Author List

  • Agapov EV; Razumov IA; Frolov IV; Kolykhalov AA; Netesov SV; Loktev VB
  • Start Page

  • 173
  • End Page

  • 181
  • Volume

  • 139
  • Issue

  • 1-2