Expression of Hel-N1 and Hel-N2 in small-cell lung carcinoma.

Academic Article


  • Hel-N1 and HuD are neuron-specific RNA-binding proteins that are antigenic targets of anti-Hu antibodies. Although expression of Hu antigens is most commonly seen in small-cell lung carcinoma, their exact identity (e.g., Hel-NI, Hel-N2, HuD, and HuC cannot be distinguished by immunological methods. Analysis of messenger RNA expression is needed for this distinction. Here we demonstrate that Hel-NI and Hel-N2 are expressed in small-cell lung carcinoma using reverse transcription-polymerase chain reaction.
  • Authors

    Published In


  • Base Sequence, Carcinoma, Small Cell, DNA Primers, ELAV Proteins, ELAV-Like Protein 2, ELAV-Like Protein 4, Gene Expression Regulation, Neoplastic, Humans, Isomerism, Leukemia, Erythroblastic, Acute, Lung Neoplasms, Molecular Sequence Data, Nerve Tissue Proteins, Polymerase Chain Reaction, RNA-Binding Proteins, Tumor Cells, Cultured
  • Digital Object Identifier (doi)

    Author List

  • King PH; Dropcho EJ
  • Start Page

  • 679
  • End Page

  • 681
  • Volume

  • 39
  • Issue

  • 5