Ribavirin small-particle aerosol treatment of infections caused by influenza virus strains A/Victoria/7/83 (H1N1) and B/Texas/1/84.

Academic Article

Abstract

  • In a double-blind study of influenza in a population of college students in 1984, ribavirin small-particle aerosol treatment of 38 patients (18 treated, 20 control) infected with a new antigenic variant, influenza virus strain A/Victoria/7/83 (H1N1), was associated with statistically significant reductions in the height and duration of fever, systemic symptoms, and virus shedding. Patients received a total of 2.4 g of ribavirin over 42 h during 68 h of hospitalization without any side effects. In addition, in a study of patients infected with influenza virus strain B/Texas/1/84 (seven treated, eight control) treated with ribavirin aerosol showed a trend of more rapid recovery than control patients.
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    Published In

    Keywords

  • Aerosols, Clinical Trials as Topic, Double-Blind Method, Female, Hemagglutination Inhibition Tests, Hematocrit, Humans, Influenza A Virus, H1N1 Subtype, Influenza A virus, Influenza B virus, Influenza, Human, Leukocyte Count, Male, Random Allocation, Ribavirin, Ribonucleosides
  • Digital Object Identifier (doi)

    Author List

  • Gilbert BE; Wilson SZ; Knight V; Couch RB; Quarles JM; Dure L; Hayes N; Willis G
  • Start Page

  • 309
  • End Page

  • 313
  • Volume

  • 27
  • Issue

  • 3