NFAT transcription factors - New players in the pathogenesis of inflammatory arthropathies?

Academic Article

Abstract

  • Inflammatory arthropathies are characterized by major changes in gene expression, which-ultimately-result from differential activities of intracellular signaling pathways and their associated inducible transcription factors. The nuclear factor of activated T cells' (NFAT) family of transcription factors plays diverse roles in a variety of processes in the immune system and other tissues. Preliminary evidence has recently emerged implicating NFAT family members directly in the pathogenesis of inflammatory arthropathies. Specific anti-NFAT drug therapy may add to the pharmacologic armamentarium against rheumatoid arthritis, other inflammatory arthropathies, and related autoimmune disorders. © 2005 Elsevier B.V. All rights reserved.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Pessler F; Dai L; Cron RQ; Schumacher HR
  • Start Page

  • 106
  • End Page

  • 110
  • Volume

  • 5
  • Issue

  • 2 SPEC. ISS.