Development and validation of an HPLC-MS/MS analytical method for quantitative analysis of TCBA-TPQ, a novel anticancer makaluvamine analog, and application in a pharmacokinetic study in rats

Academic Article

Abstract

  • We have recently designed and synthesized several novel iminoquinone anticancer agents that have entered preclinical development for the treatment of human cancers. Herein we developed and validated a quantitative HPLC-MS/MS analytical method for one of the lead novel anticancer makaluvamine analog, TCBA-TPQ, and conducted a pharmacokinetic study in laboratory rats. Our results indicated that the HPLC-MS/MS method was precise, accurate, and specific. Using this method, we carried out in vitro and in vivo evaluations of the pharmacological properties of TCBA-TPQ and plasma pharmacokinetics in rats. Our results provide a basis for future preclinical and clinical development of this promising anticancer marine analog.
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 18480663
  • Author List

  • Yu JX; Voruganti S; Li DD; Qin JJ; Nag S; Xu S; Velu SE; Wang W; Zhang R
  • Start Page

  • 554
  • End Page

  • 560
  • Volume

  • 13
  • Issue

  • 7