Synthesis and preliminary assessment of the anticancer and Wnt/β-catenin inhibitory activity of small amide libraries of fenamates and profens

Academic Article

Abstract

  • As part of an ongoing program to study the anticancer activity of non-steroidal anti-inflammatory drugs (NSAIDs) through generating diversity libraries of multiple NSAID scaffolds, we synthesized a series of NSAID amide derivatives and screened these sets against three cancer cell lines (prostate, colon and breast) and Wnt/β-catenin signaling. The evaluated amide analog libraries show significant anticancer activity/cell proliferation inhibition, and specific members of the sets show inhibition of Wnt/β-catenin signaling.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Mathew B; Hobrath JV; Lu W; Li Y; Reynolds RC
  • Start Page

  • 3038
  • End Page

  • 3045
  • Volume

  • 26
  • Issue

  • 11