Optimization of a multi-well array SERS chi

Academic Article


  • SERS-active substrates are fabricated by oblique angle deposition and patterned by a polymer-molding technique to provide a uniform array for high throughput biosensing and multiplexing. Using a conventional SERS-active molecule, 1,2-Bis(4-pyridyl)ethylene (BPE), we show that this device provides a uniform Raman signal enhancement from well to well. The patterning technique employed in this study demonstrates a flexibility allowing for patterning control and customization, and performance optimization of the substrate. Avian influenza is analyzed to demonstrate the ability of this multi-well patterned SERS substrate for biosensing. ©2009 SPIE.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Abell JL; Driskell JD; Dluhy RA; Tripp RA; Zhao YP
  • Volume

  • 7321