Stereoselective binding of an enantiomeric pair of stromelysin-1 inhibitors caused by conformational entropy factors

Academic Article


  • Isothermal titration calorimetry was used to analyze the binding of an enantiomeric pair of inhibitors to the stromelysin-1 catalytic domain. Differences in binding affinity are attributable to different conformational entropy penalties suffered upon binding. Two possible explanations for these differences are proposed. (C) 2000 Elsevier Science Ltd.
  • Digital Object Identifier (doi)

    Author List

  • Parker MH; Ortwine DF; O'Brien PM; Lunney EA; Banotai CA; Mueller WT; McConnell P; Brouillette CG
  • Start Page

  • 2427
  • End Page

  • 2430
  • Volume

  • 10
  • Issue

  • 21