This study examined the attitudes and practices of a sample of White (N = 667) and American Indian (N = 280) adolescents in regard to the use of alcohol and other drugs. The findings lend general support to the hypothesis of Whitehead et al. that users of any one drug will show increased probability to use another drug when compared to those not using that drug. Additionally, it was found that rural Indian youth are somewhat more likely than rural White youth to be involved with alcohol, marijuana, and hard drugs. © 1977 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.