Sodium fluxes and astroglial function.

Academic Article


  • Astrocytes exhibit their excitability based on variations in cytosolic Ca(2+) levels, which leads to variety of signalling events. Only recently, however, intracellular fluctuations of more abundant cation Na(+) are brought in the limelight of glial signalling. Indeed, astrocytes possess several plasmalemmal molecular entities that allow rapid transport of Na(+) across the plasma membrane: (1) ionotropic receptors, (2) canonical transient receptor potential cation channels, (3) neurotransmitter transporters and (4) sodium-calcium exchanger. Concerted action of these molecules in controlling cytosolic Na(+) may complement Ca(2+) signalling to provide basis for complex bidirectional astrocyte-neurone communication at the tripartite synapse.
  • Keywords

  • Animals, Astrocytes, Calcium Signaling, Cell Communication, Cell Membrane, Humans, Ion Transport, Neurons, Sodium, Sodium-Calcium Exchanger, Sodium-Potassium-Exchanging ATPase
  • Digital Object Identifier (doi)

    Author List

  • Verkhratsky A; Noda M; Parpura V; Kirischuk S
  • Start Page

  • 295
  • End Page

  • 305
  • Volume

  • 961