The ubiquitin-specific protease 14 (USP14) is a critical regulator of long-term memory formation.

Academic Article


  • Numerous studies have suggested a role for ubiquitin-proteasome-mediated protein degradation in learning-dependent synaptic plasticity; however, very little is known about how protein degradation is regulated at the level of the proteasome during memory formation. The ubiquitin-specific protease 14 (USP14) is a proteasomal deubiquitinating enzyme that is thought to regulate protein degradation in neurons; however, it is unknown if USP14 is involved in learning-dependent synaptic plasticity. We found that infusion of a USP14 inhibitor into the amygdala impaired long-term memory for a fear conditioning task, suggesting that USP14 is a critical regulator of long-term memory formation in the amygdala.
  • Published In


  • Acoustic Stimulation, Amygdala, Analysis of Variance, Animals, Conditioning, Classical, Dose-Response Relationship, Drug, Enzyme Inhibitors, Fear, Male, Memory Disorders, Memory, Long-Term, Rats, Rats, Long-Evans, Ubiquitin Thiolesterase
  • Digital Object Identifier (doi)

    Author List

  • Jarome TJ; Kwapis JL; Hallengren JJ; Wilson SM; Helmstetter FJ
  • Start Page

  • 9
  • End Page

  • 13
  • Volume

  • 21
  • Issue

  • 1