Genetic changes in the pathogenesis of lung cancer

Academic Article


  • Human lung cancer is a complex genetic disease resulting from a series of inherited and somatically occurring defects in a number of critical genes. These genetic events, produced in part by carcinogen exposure, include chromosomal deletion, rearrangement, and mutation, and lead to inactivation or activation of certain target genes. Recent data showed these genes to include both recessive oncogenes such as the retinoblastoma gene and dominantly acting oncogenes such as the myc and ras family members.
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 24814971
  • Author List

  • Birrer MJ; Minna JD
  • Start Page

  • 305
  • End Page

  • 317
  • Volume

  • 40