Use of transcription factors as agents and targets for drug development

Academic Article

Abstract

  • Cells respond to external signals by either activating or inhibiting key regulatory proteins of gene expression called transcription factors (TFs). Abnormal expression of these factors play a critical role in many human cancers. Recently, many TFs have been identified and their structure-function relationship has been characterized. Such new information has been useful in designing new chemotherapeutic drugs targeting these regulatory proteins. This review discusses the use of dominant-negative (DN) mutants of TFs as inhibitors of cell growth, as well as possible strategies for screening potential inhibitors of TF activity.
  • Published In

  • Oncology  Journal
  • Author List

  • Smith LM; Birrer MJ
  • Start Page

  • 1532
  • End Page

  • 1538
  • Volume

  • 10
  • Issue

  • 10