Abnormal fragile histidine triad (FHIT) expression in advanced cervical carcinoma: A poor prognostic factor

Academic Article


  • The FHIT gene is a candidate tumor suppressor gene that has been implicated in the development of cervical carcinoma. We hypothesized that abnormal Fhit expression might be a poor prognostic factor for patients with cervical cancer. The tumors from 59 high-risk patients (stage II-III) were evaluated for abnormal Fhit expression by immunohistochemical staining. Abnormal Fhit expression (absent or reduced) was noted in 66% of the specimens. There was no statistical difference with respect to stage, performance status, para-aortic node metastasis, completion of therapy, grade, race, age, and HIV status between the normal and abnormal Fhit expression groups. The 3-year survival for patients whose tumors displayed normal Fhit expression versus abnormal Fhit expression was 74% versus 37%, respectively. Univariate analysis demonstrated a difference in survival that was statistically significant for age <55 years versus ≥55 years (P = 0.015), normal Fhit expression versus abnormal Fhit expression (P = 0.015), and stage II versus stage III (P = 0.033). Multivariate analysis showed that abnormal Fhit expression was a poor prognostic factor (P = 0.015).
  • Published In

  • Cancer Research  Journal
  • Author List

  • Krivak TC; McBroom JW; Seidman J; Venzon D; Crothers B; MacKoul PJ; Rose GS; Carlson JW; Birrer MJ
  • Start Page

  • 4382
  • End Page

  • 4385
  • Volume

  • 61
  • Issue

  • 11