A polymorphism in the GALNT2 gene and ovarian cancer risk in four population based case-control studies

Academic Article

Abstract

  • Recent epidemiologic evidence supports a role for MUC1 in ovarian carcinogenesis; therefore, we hypothesized that common genetic variation in the genes responsible for glycosylation of MUC1 may influence ovarian cancer risk. In a genome-wide association study of ovarian cancer, we observed an association between a non-synonymous SNP (rs2271077) in the UDP-N-acetyl-alpha-d-galactosamine: polypeptide N-acetylgalactosainyltransferase 2 (GALNT2) gene and ovarian cancer risk (p=0.005). We sought to validate the association in four population based ovarian cancer case-control studies collaborating through the Ovarian Cancer Association Consortium. Although rs2271077 was associated with a significantly increased risk (Odds Ratio (OR) = 1.37, 95% Confidence Interval (CI) =1.06-1.77) in one study with 961 cases and 922 controls, we observed no association in the remaining three studies including 1452 cases and 1954 controls (OR=0.83, 95% CI= 0.66-1.04). Therefore, there appears to be no strong evidence of association between GALNT2 SNP rs2271077 and ovarian cancer risk.
  • Pubmed Id

  • 24588985
  • Author List

  • Terry KL; Vitonis AF; Hernandez D; Lurie G; Song H; Ramus SJ; Titus-Ernstoff L; Carney ME; Wilkens LR; Gentry-Maharaj A
  • Start Page

  • 272
  • End Page

  • 277
  • Volume

  • 1
  • Issue

  • 4