Common variants at 19p13 are associated with susceptibility to ovarian cancer

Academic Article

Abstract

  • Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women. We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5×10 -4 and P = 6×10 -4 , respectively), but they did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P = 3×10 -9 and P = 4×10 -11 , respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development. © 2010 Nature America, Inc. All rights reserved.
  • Digital Object Identifier (doi)

    Author List

  • Bolton KL; Tyrer J; Song H; Ramus SJ; Notaridou M; Jones C; Sher T; Gentry-Maharaj A; Wozniak E; Tsai YY
  • Start Page

  • 880
  • End Page

  • 884
  • Volume

  • 42
  • Issue

  • 10