Bioactive benzofuran derivatives from cortex mori radicis, and their neuroprotective and analgesic activities mediated by mGluR1

Academic Article

Abstract

  • © 2017 by the authors; licensee MDPI, Basel, Switzerland. Four new benzofuran-type stilbene glycosides and 14 known compounds including 8 benzofuran-type stilbenes and 6 flavonoids were isolated from the traditional Chinese medicine, Cortex Mori Radicis. The new compounds were identified as (9R)-moracin P 3′-O-α-L-arabinopyranoside (1), (9R)-moracin P 9-O-β-D-glucopyranoside (2), (9R)-moracin P 3′-O-β-D-glucopyranoside (3), and (9R)-moracin O 10-O-β-D-glucopyranoside (4) based on the spectroscopic interpretation and chemical analysis. Three benzofuran-type stilbenes, moracin O (5), R (7), and P (8) showed significant neuroprotective activity against glutamate-induced cell death in SK-N-SH cells. In addition, moracin O (5) and P (8) also demonstrated a remarkable inhibition of the acetic acid-induced pain. The molecular docking with metabotropic glutamate receptor 1 (mGluR1) results indicated that these neuroprotective benzofuran-type stilbenes might be the active analgesic components of the genus Morus, and acted by mediating the mGluR1 pathway.
  • Authors

    Published In

  • Molecules  Journal
  • Digital Object Identifier (doi)

    Author List

  • Wang YN; Liu MF; Hou WZ; Xu RM; Gao J; Lu AQ; Xie MP; Li L; Zhang JJ; Peng Y
  • Volume

  • 22
  • Issue

  • 2