Fetal rat hyperinsulinism and hyperglucagonism: Effects on hepatic ketogenesis, lipogenesis, and gluconeogenesis

Academic Article


  • To study the direct effects of hyperglucagonism and hyperinsulinism (both with glucose excess) on fetal intermediary metabolism, rat liver explants from 19-day-gestated fetuses were maintained in culture for 48 h. The liver cubes were exposed to 0, 250, or 500 mU/ml porcine insulin or 5 Mg/ml glucagon. In addition, lipogenesis from 3H2O was cumulated throughout the 48 h. Chronic hyperinsulinism in the fetal rat doubled hepatic lipogenesis and curtailed hepatic gluconeogenesis and ketogenesis by 80% and 50%, respectively. Chronic hyperglucagonism was without effect; however, the fetal liver did yet respond to 1 mM (Bu)2cAMP. © 1985 by The Endocrine Society.
  • Published In

  • Endocrinology  Journal
  • Digital Object Identifier (doi)

    Author List

  • McCormick K; Donlon E; Dziwis P
  • Start Page

  • 1281
  • End Page

  • 1287
  • Volume

  • 116
  • Issue

  • 4