Susceptibility of Mycobacterium tuberculosis cytochrome bd oxidase mutants to compounds targeting the terminal respiratory oxidase, cytochrome c

Academic Article

Abstract

  • © 2017 American Society for Microbiology. All Rights Reserved. We deleted subunits I (cydA) and II (cydB) of the Mycobacterium tuberculosis cytochrome bd menaquinol oxidase. The resulting ΔcydA and ΔcydAB mutants were hypersusceptible to compounds targeting the mycobacterial bc1 menaquinol-cytochrome c oxidoreductase and exhibited bioenergetic profiles indistinguishable from strains deficient in the ABC-type transporter, CydDC, predicted to be essential for cytochrome bd assembly. These results confirm CydAB and CydDC as potential targets for drugs aimed at inhibiting a terminal respiratory oxidase implicated in pathogenesis.
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    Author List

  • Moosa A; Lamprecht DA; Arora K; Barry CE; Boshoff HIM; Ioerger TR; Steyn AJC; Mizrahi V; Warner DF
  • Volume

  • 61
  • Issue

  • 10