REACTIVE ARTHRITIS has been a well-documented consequence of infection with certain enteric pathogens. The leading bacterial triggers are Salmonella, Shigella, Yersinia, and Campylobacter species. The number of reports of reactive arthritis occurring following gastrointestinal infection with Clostridium difficile has recently increased. The first case of reactive arthritis following C difficile pseudomembranous colitis was reported in 1976. In the past 20 years, 22 cases of reactive arthritis or Reiter's syndrome associated with C difficile have been reported. All 22 patients were adults, the youngest being 22 years old. Herein we report the first case of reactive arthritis to C difficile in a child and review the literature on adult cases.