The Cure4Kids Website (www.Cure4Kids.org) brings the latest medical knowledge and continuing education on the treatment of pediatric catastrophic diseases to thousands of health care providers worldwide. The website offers a digital library, on-demand seminars with slides and audio in several languages, and online meeting rooms for international collaborations. In this paper, we describe the design challenges of the Cure4Kids Website as an online learning and collaboration center, including the web interface design, content organization, and usability. The solutions to these design challenges may help other web designers facing similar issues in the design of international web-based projects. © 2008 John Benjamins Publishing Company.