The phenotypic characteristics of heterozygous reeler mouse

Academic Article

Abstract

  • Histological and behavioral traits are associated with reelin (Reln) haplo-insufficiency in heterozygous reeler mouse (rl+/-). These phenotypic traits are an ~50% decrease of brain Reln mRNA and Reln protein, an accumulation of nicotinamide-adenine dinucleotide phosphate-diaphorase (NADPH-d)-positive neurons in subcortical white matter, an age-dependent decrease in prepulse inhibition of startle (PPI), and neophobic behavior on the elevated plus-maze. Possible analogies between these rl+/- phenotypic traits and signs of psychosis vulnerability are discussed.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Tueting P; Costa E; Dwivedi Y; Guidotti A; Impagnatiello F; Manev R; Pesold C
  • Start Page

  • 1329
  • End Page

  • 1334
  • Volume

  • 10
  • Issue

  • 6