Novel quinolizidine salicylamide influenza fusion inhibitors.

Academic Article

Abstract

  • A novel series of quinolizidine salicylamides was synthesized as specific inhibitors of the H1 subtype of influenza A viruses. These inhibitors inhibit the pH-induced fusion process, thereby blocking viral entry into host cells. Compound 16 was the most active inhibitor in this series with an EC50 of 0.25 microg/mL in plaque reduction assay. The synthesis and the SAR of these compounds are discussed.
  • Keywords

  • Animals, Antiviral Agents, Cattle, Cells, Cultured, Influenza A virus, Quinolizines, Salicylamides, Structure-Activity Relationship
  • Digital Object Identifier (doi)

    Author List

  • Yu KL; Ruediger E; Luo G; Cianci C; Danetz S; Tiley L; Trehan AK; Monkovic I; Pearce B; Martel A
  • Start Page

  • 2177
  • End Page

  • 2180
  • Volume

  • 9
  • Issue

  • 15