Salicylamide inhibitors of influenza virus fusion.

Academic Article

Abstract

  • Structural variation of the quinolizidine heterocycle of the influenza fusion inhibitor BMY-27709 was examined by several topological dissections in order to illuminate the critical features of the ring system. This exercise resulted in the identification of a series of synthetically more accessible decahydroquinolines that retained the structural elements of BMY-27709 important for antiviral activity. The 2-methyl-cis-decahydroquinoline 6f was the most potent influenza inhibitor identified that demonstrated an EC50 of 90 ng/mL in a plaque reduction assay.
  • Keywords

  • Animals, Antiviral Agents, Cell Line, Dogs, Membrane Fusion, Orthomyxoviridae, Quinolizines, Salicylamides
  • Digital Object Identifier (doi)

    Author List

  • Combrink KD; Gulgeze HB; Yu KL; Pearce BC; Trehan AK; Wei J; Deshpande M; Krystal M; Torri A; Luo G
  • Start Page

  • 1649
  • End Page

  • 1652
  • Volume

  • 10
  • Issue

  • 15