Structure-activity relationships for a series of thiobenzamide influenza fusion inhibitors derived from 1,3,3-trimethyl-5-hydroxy-cyclohexylmethylamine.

Academic Article

Abstract

  • The anti-influenza activity of a series of thiobenzamide fusion inhibitors derived from 1,3,3-trimethyl-5-hydroxy-cyclohexylmethylamine is profiled. Axial disposition of the thioamide moiety is essential for potent influenza inhibitory activity.
  • Keywords

  • Animals, Antiviral Agents, Cells, Cultured, Dogs, Drug Evaluation, Preclinical, Hemolysis, Inhibitory Concentration 50, Membrane Fusion, Methylamines, Orthomyxoviridae, Quinolizines, Stereoisomerism, Structure-Activity Relationship, Thioamides
  • Digital Object Identifier (doi)

    Author List

  • Yu KL; Torri AF; Luo G; Cianci C; Grant-Young K; Danetz S; Tiley L; Krystal M; Meanwell NA
  • Start Page

  • 3379
  • End Page

  • 3382
  • Volume

  • 12
  • Issue

  • 23