Inflammation-induced interstitial migration of effector CD4+ T cells is dependent on integrin α v

Academic Article

Abstract

  • Leukocytes must traverse inflamed tissues to effectively control local infection. Although motility in dense tissues seems to be integrin independent and based on actomyosin-mediated protrusion and contraction, during inflammation, changes to the extracellular matrix (ECM) may necessitate distinct motility requirements. Indeed, we found that the interstitial motility of T cells was critically dependent on Arg-Gly-Asp (RGD)-binding integrins in the inflamed dermis. Inflammation-induced deposition of fibronectin was functionally linked to higher expression of integrin α V on effector CD4+ T cells. By intravital multiphoton imaging, we found that the motility of CD4+ T cells was dependent on α V expression. Selective blockade or knockdown of α V arrested T helper type 1 (T H 1) cells in the inflamed tissue and attenuated local effector function. Our data demonstrate context-dependent specificity of lymphocyte movement in inflamed tissues that is essential for protective immunity. © 2013 Nature America, Inc. All rights reserved.
  • Published In

  • Nature Immunology  Journal
  • Digital Object Identifier (doi)

    Author List

  • Overstreet MG; Gaylo A; Angermann BR; Hughson A; Hyun YM; Lambert K; Acharya M; Billroth-Maclurg AC; Rosenberg AF; Topham DJ
  • Start Page

  • 949
  • End Page

  • 958
  • Volume

  • 14
  • Issue

  • 9