The Lymphotoxin LTα1β2 Controls Postnatal and Adult Spleen Marginal Sinus Vascular Structure and Function

Academic Article


  • The lymphotoxin LTα β supports the development and maintenance of several aspects of spleen structure, but its significance for marginal sinus (MS) vascular organization is unclear. We showed here that, in early postnatal lymphotoxin-deficient mice, the developing Flk-1 white pulp vessels failed to organize or upregulate MAdCAM-1, leading to altered spatial rearrangement of both the white pulp endothelial cells and the smooth muscle actin-expressing cells. In vitro, MAdCAM-1 directed the reorganization of LTβ receptor endothelial cells grown on Matrigel. LTα β also regulated the maintenance of both MAdCAM-1 expression and mature MS structure in adult mice, contributing importantly to normal trafficking of CD11b cells in response to bacterial antigens. Together, our studies demonstrate that LTα β and LTβ receptor signals control proper development and maintenance of the mature MS structure and implicate MAdCAM-1 in the structuring of the MS endothelial cells that is important for the movement of immune cells within the spleen. © 2009 Elsevier Inc. All rights reserved. 1 2 1 2 1 2 + + +
  • Published In

  • Immunity  Journal
  • Digital Object Identifier (doi)

    Author List

  • Zindl CL; Kim TH; Zeng M; Archambault AS; Grayson MH; Choi K; Schreiber RD; Chaplin DD
  • Start Page

  • 408
  • End Page

  • 420
  • Volume

  • 30
  • Issue

  • 3