TGF-beta downregulation of distinct chloride channels in cystic fibrosis-affected epithelia

Academic Article

Abstract

  • Rationale: The cystic fibrosis transmembrane conductance regulator (CFTR) and Calcium-activated Chloride Conductance (CaCC) each play critical roles in maintaining normal hydration of epithelial surfaces including the airways and colon. TGFbeta is a genetic modifier of cystic fibrosis (CF), but how it influences the CF phenotype is not understood.
  • Published In

  • PLoS ONE  Journal
  • Digital Object Identifier (doi)

    Author List

  • Sun H; Harris WT; Kortyka S; Kotha K; Ostmann AJ; Rezayat A; Sridharan A; Sanders Y; Naren AP; Clancy JP
  • Volume

  • 9
  • Issue

  • 9