Estimation of extracellular fluid volume from plasma clearance on Technetium-99m DTPA by a single-injection, two-sample method

Academic Article


  • A simple method is presented for estimating extracellular fluid volume from the plasma clearance of [99Tc]DPTA or [169Yb]DTPA. Two plasma samples are required, at 1 hr and 3 hr, following a single intravenous injection. (The same plasma samples can be used for measurement of glomerular filtration rate.) Using the complete plasma clearance curve as a reference (eight samples at 10 to 240 min), the error of the two-sample method in 40 patients was 1.5 l for [99mTc]DPTA, 2.1 l for [169Yb]DTPA (residual standard deviation.
  • Published In

    Author List

  • Russel CD; Bischoff PG; Rowell KL; Lloyd LK; Dubovsky EV
  • Start Page

  • 255
  • End Page

  • 258
  • Volume

  • 29
  • Issue

  • 2