Objective: The purpose of this study was to compare outcomes after sacrocolpopexy (SC) between obese and healthy-weight women. Study Design: Baseline and postoperative data were analyzed from the Colpopexy And Urinary Reduction Efforts (CARE) randomized trial of SC with or without Burch colposuspension in stress continent women with stages II-IV prolapse. Outcomes and complications were compared between obese and healthy-weight women. Results: CARE participants included 74 obese (body mass index ≥30 kg/m2), 122 overweight (25-29.9 kg/m2), and 125 healthy-weight (18.5-24.9 kg/m2) women, and 1 underweight (< 18.5 kg/m2) woman. Compared to healthy-weight women, obese women were younger (59.0 ± 9.9 vs 62.1 ± 10.3 yrs; P = .04), more likely to have stage II prolapse (25.7% vs 11.2%; P = .01), and had longer operative times (189 ± 52 vs 169 ± 58 min; P = .02). Two years after surgery, stress incontinence, prolapse, symptom resolution, and satisfaction did not differ between the obese and healthy-weight groups. Conclusion: Most outcomes and complication rates after SC are similar in obese and healthy-weight women. © 2008 Mosby, Inc. All rights reserved.