Do short-term markers of treatment efficacy predict long-term sequelae of pelvic inflammatory disease?

Academic Article


  • Objective: This study was undertaken to assess whether short-term markers, often used to measure clinical cure after treatment for pelvic inflammatory disease, predict sequelae of lack of pregnancy, recurrent pelvic inflammatory disease, and chronic pelvic pain. Study Design: Women with mild-to-moderate pelvic inflammatory disease were assessed after treatment initiation at 5 days for tenderness (n = 713) and at 30 days for tenderness, cervical infections and endometritis (n = 298). Pregnancy, recurrent pelvic inflammatory disease, and chronic pelvic pain were evaluated after 84 months, on average. Results: Pelvic tenderness at 5 and at 30 days significantly elevated the risk for developing chronic pelvic pain; tenderness at 30 days was also significantly associated with recurrent pelvic inflammatory disease. However, pelvic tenderness at 5 and at 30 days was only modestly clinically predictive of chronic pelvic pain or recurrent pelvic inflammatory disease (positive predictive values 22.1-66.9%). No short-term marker significantly influenced the likelihood of achieving a pregnancy. Conclusion: Tenderness at 5 or 30 days did not accurately predict the occurrence of pelvic inflammatory disease-related reproductive morbidities. © 2008 Mosby, Inc. All rights reserved.
  • Authors

    Digital Object Identifier (doi)

    Pubmed Id

  • 3839474
  • Author List

  • Trautmann GM; Kip KE; Richter HE; Soper DE; Peipert JF; Nelson DB; Trout W; Schubeck D; Bass DC; Ness RB
  • Start Page

  • 30.e1
  • End Page

  • 30.e7
  • Volume

  • 198
  • Issue

  • 1