Radiolabeling of monoclonal antibody against carcinoembryonic antigen with 88 Y and biodistribution studies

Academic Article

Abstract

  • The biodistribution of the 202 monoclonal antibody against CEA labeled with 88 Y by the bicyclic DTPA anhydride method was studied in normal Balb/c mice. The in vitro binding to 1 × 10 7 CO112, LS174T and WiDR colon cancer cells was 21.0, 27.3 and 18.8%, respectively. The binding to an equal number of KM-3 leukemia cells and normal human lymphocytes was 8.9 and 3.2%, respectively. Liver, spleen, kidney and blood were the tissues that showed the highest uptake of radiolabeled antibody in vivo. © 1985.
  • Digital Object Identifier (doi)

    Author List

  • Buchsbaum DJ; Hanna DE; Randall BC; Buchegger F; Mach JP
  • Start Page

  • 79
  • End Page

  • 82
  • Volume

  • 12
  • Issue

  • 2