3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and the presence of age-related macular degeneration in the cardiovascular health study

Academic Article


  • Objective: To evaluate both the use of cholesterol-lowering medications as a group and the use of statins specifically with regard to the risk of age-related macular degeneration (AMD). Methods: A case-control study was conducted using data from the Cardiovascular Health Study, a population-based prospective study of adults enrolled from 4 communities in the United States in 1989 and 1990. Individuals with AMD (cases) and those without AMD (controls) were compared with regard to their use of cholesterol-lowering medications and statins. Results: Nearly equal proportions of cases and controls used cholesterol-lowering medications, both before adjustment (odds ratio, 0.92; 95% confidence interval, 0.70-1.21) and after adjustment for selected confounding variables (age, sex, and race) (odds ratio, 1.35; 95% confidence interval, 0.98-1.87). Statin use was also found to be similar among cases and controls (odds ratio, 0.98; 95% confidence interval, 0.73-1.30). After controlling for the aforementioned 3 confounders (odds ratio, 1.40; 95% confidence interval, 0.99-1.98), we noted a modest trend for statin users to have an increased risk of AMD. Conclusion: The results suggest that no association exists between having used cholesterol-lowering medications and AMD. However, there was a suggestion that statin use might increase the risk of AMD. ©2006 American Medical Association. All rights reserved.
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    Digital Object Identifier (doi)

    Author List

  • McGwin G; Modjarrad K; Hall TA; Xie A; Owsley C
  • Start Page

  • 33
  • End Page

  • 37
  • Volume

  • 124
  • Issue

  • 1