Successful treatment of preadolescents with small cell carcinoma of the ovary hypercalcemic type

Academic Article


  • BACKGROUND:: Small cell carcinoma of the ovary hypercalcemic type (SCCOHT) is a rare tumor with a peak incidence in young adulthood that historically has carried a poor prognosis. OBSERVATIONS:: We present 2 advanced stage cases of SCCOHT in preadolescents successfully treated with a combination of cisplatin-based chemotherapy and surgical resection. The more recent patient also underwent consolidative high-dose chemotherapy with stem cell rescue and external beam radiotherapy. Her therapy was concluded with a maintenance course of bevacizumab. The patients are now disease-free 7 years and 30 months, respectively, after diagnosis. CONCLUSIONS:: With aggressive multimodal therapy SCCOHT is curable in children. Copyright © 2013 by Lippincott Williams & Wilkins.
  • Authors

    Digital Object Identifier (doi)

    Pubmed Id

  • 21262390
  • Author List

  • Pressey JG; Kelly DR; Hawthorne HT
  • Start Page

  • 566
  • End Page

  • 569
  • Volume

  • 35
  • Issue

  • 7